TY - T1的回顾性评价Neuropathologic代理的最小萎缩亚型相比Corticolimbic阿尔茨海默病亚型JF -神经学乔-神经- 10.1212 / WNL。首页0000000000207685 SP - 10.1212 / WNL。0000000000207685 AU - Baayla迪米特里Catharina恩惠AU -悉尼Labuzan盟中卫彭Kouri AU -比利Matchett盟内奥米非盟-凯利米亨盟基督教Lachner AU -欧文罗斯盟Nilufer Ertekin-Taner AU -里基·e·卡特AU -坦尼斯j . Ferman盟Ranjan这盟-丹尼斯·w·迪克森盟-尼尔Graff-Radford盟梅丽莎·e·默里Y1 - 2023/08/14 UR - //www.ez-admanager.com/content/early/2023/08/14/WNL.0000000000207685.abstract N2 -背景:阿尔茨海默病(AD)是神经病理学分为三个corticolimbic基于神经原纤维缠结的亚型分布在海马和联合皮层:边缘的,典型的首页,海马爱惜。体内,第四个亚型,被称为“最小的萎缩”,被发现使用结构磁共振成像。摘要目的:本研究的目的是确定一个neuropathologic neuroimaging-defined最小萎缩亚型的代理。方法:我们应用两种策略的佛罗里达解剖多民族(火焰)群组评价neuropathologic最小萎缩亚型的代理。在第一个策略中,我们选择广告例Braak IV混乱阶段,因为皮层纠结参与Braak>相比的相对缺乏;第四。Braak第四例相比,三个亚型。在另一种策略,典型的广告是由大脑重量和分层的情况下有一个相对较高的脑重量(在第75个百分位)被定义为最小的萎缩。结果:Braak 4例(n = 37)与广告不同亚型(边缘主要(n = 174),典型的(n = 986),保留和海马(n = 187)广告)方面有多年的教育(12年,中位数group-wise术;0.001)和最高的脑重量(平均1140克,p = 0.002)。Braak IV情况下最相似的边缘的情况下由于高比例的APOEε4运营商(75%,术中;0.001),一个遗忘综合征(100%,术中;0.001),以及老年认知症状出现和死亡(中位数分别在79年和85年,术中,0.001)。 Only 5% of Braak IV had amygdala predominant Lewy bodies (the lowest frequency observed, p=0.017), whereas 32% had coexisting pathology of Lewy body disease which was greater than the other subtypes (p=0.005). Nearly half (47%) of the Braak IV sample had coexisting limbic-predominant age-related TDP-43 encephalopathy neuropathologic change. Cases with a high brain weight (n=201) were less likely to have amygdala predominant Lewy bodies (14%, p=0.006) and most likely to have Lewy body disease (31%, p=0.042) compared to those with middle (n=455) and low brain weight (n=203).Discussion: The frequency of Lewy body disease was increased in both neuropathologic proxies of the minimal atrophy subtype. We hypothesize that Lewy body disease may underlie cognitive decline observed in minimal atrophy cases. ER -