% 0期刊文章%一个亨氏Krestel % David R . Schreier % Elmaze Sakiri %一个Andreas von Allmen % Yasmina Abukhadra % Arto Nirkko %一个Maja Steinlin %一个符文Markhus Felix罗斯诺夫% %一个戈比施耐德%卡罗琳Jagella %一个哈尔Blumenfeld约翰内斯·马修斯% % T发作痫性放电的预测能力Fitness-to-Drive评价% D R 10.1212 / WNL 2023%。0000000000207531 % J首页神经病学% P e866-e878 % V 101% N 9% X背景和目标本研究旨在评估和预测发作痫性放电的影响(ied)驾驶能力测试和驾驶模拟器使用简单的反应。方法不同的癫痫病患者评估同时脑电图在单闪灯测试他们对视觉刺激的反应,汽车视频游戏和现实的驾驶模拟器。反应时间(RTs)和错过的反应或崩溃(小姐/崩溃)在正常脑电图和简易爆炸装置测量。简易爆炸装置,在这项研究中,考虑一系列的癫痫样的潜力(> 1潜力),分为广义典型,广义非典型或焦点。RT和小姐/崩溃与简易爆炸装置类型、持续时间和测试类型进行了分析。RT延长,小姐/碰撞概率,比值比(或)小姐/事故由于计算简易爆炸装置。结果广义典型的ied RT延长了164 ms,而广义非典型ied (77.0 ms)和焦ied (48.0 ms) (p < 0.01)。广义典型简易爆炸装置有一个会话小姐/事故的概率14.7%焦和广义非典型ied零值(p < 0.01)。长期重复的焦ied持久> 2秒错过了2.6% / probabilityIED崩溃。累积小姐/ RT延长碰撞概率可以预测:90.3取得了20%的小姐/女士碰撞概率。所有的测试都互相nonsuperior探测小姐/崩溃probabilitiesIED(零值为所有3测试)或RT拖长某个(flash测试:56.4毫秒,汽车电子游戏:75.5毫秒,模拟器86.6 ms)。 IEDs increased the OR of miss/crash in the simulator by 4.9-fold compared with normal EEG. A table of expected RT prolongations and miss/crash probabilities for IEDs of a given type and duration was created.Discussion IED-associated miss/crash probability and RT prolongation were comparably well detected by all tests. Long focal IED bursts carry a low risk, while generalized typical IEDs are the primary cause of miss/crash. We propose a cumulative 20% miss/crash risk at an RT prolongation of 90.3 ms as a clinically relevant IED effect. The IED-associated OR in the simulator approximates the effects of sleepiness or low blood alcohol level while driving on real roads. A decision aid for fitness-to-drive evaluation was created by providing the expected RT prolongations and misses/crashes when IEDs of a certain type and duration are detected in routine EEG.10%–90% IPR=10%–90% interpercentile range; Gen atyp=generalized atypical (IEDs); Gen typ=generalized typical (IEDs); IEDs=interictal epileptiform discharges; miss/crash=missed reactions or crashes; RTs=reaction times %U //www.ez-admanager.com/content/neurology/101/9/e866.full.pdf