文摘
摘要目的:确定后皮质萎缩的频率特性(PCA)发生在logopenic进行性失语患者(LPA)和确定这些特性的神经影像学相关。
背景:LPA和PCA是两个典型的阿尔茨海默病的临床变异。之间的重叠可以观察到的临床表型,虽然还不清楚患者LPA开发会议标准临床PCA的频率特性,以及这些特性是否与神经解剖学的重叠与PCA相关联。
设计/方法:36 LPA招募的患者神经退行性研究小组进行了广泛的神经心理学测试,MRI和[18F] flortaucipir宠物。所有患者评估PCA特征包括simultanagnosia乔综合症,观念运动的失用症,与分割点和视觉空间和visuoperceptual功能,用于定义异常。患者分为Pure-LPA(没有PCA特征),LPA +(一个测试损伤)或LPA-PCA(2 +测试障碍)。神经影像学资料相比,三种LPA组14匹配的健康对照组和14个典型PCA病人在SPM12使用多元回归分析。
结果:11例(31%)被列为pure-LPA, 16 (44%), LPA LPA-PCA + 9 (25%)。没有疾病持续时间差异,跨组命名,或句子重复。LPA +集团糟糕simultanagnosia(29%)、观念运动的失用症和乔综合症(34%)相比,Pure-LPA组。LPA-PCA组显示进一步恶化simultanagnosia(89%)、和视觉空间和visuoperceptual障碍相比,LPA +组。LPA三个组表现出更大的左颞顶体积损失和flortaucipir吸收与控制和PCA相比,更flortaucipir吸收发生在枕叶和额叶LPA +和LPA-PCA Pure-LPA相比。
结论:我们的研究结果表明,PCA LPA病人可以开发的特性相关τ蔓延到occipito-frontal地区,强调综合征和解剖重叠非典型变异的广告。
披露:辛格博士没有披露。Graff-Radford博士已经收到个人赔偿作为梅奥诊所的一名雇员。Graff-Radford博士已经收到个人补偿的范围0 - 499美元为科学顾问或服务数据安全监测委员会研究所/国家卫生研究院。Graff-Radford博士已经收到个人薪酬在5000 - 9999美元的范围作为一个编辑,副主编,或为美国神经病学学会编辑顾问委员会成员。首页Graff-Radford博士的机构收到NIH的研究支持。马里兰州Arenn Faye卡洛斯没有披露。Machulda博士的机构收到NIH的研究支持。克里斯托弗·施瓦兹收到个人赔偿作为梅奥诊所的一名雇员。克里斯托弗·施瓦兹的机构收到NIH的研究支持。马修Senjem已收到股票或对齐技术的所有权,Inc . . Matthew Senjem has received stock or an ownership interest from Inovio Biomedical Corp.. Matthew Senjem has received stock or an ownership interest from Johnson & Johnson. Matthew Senjem has received stock or an ownership interest from Mesa Laboratories, Inc.. Matthew Senjem has received stock or an ownership interest from Nvidia Inc.. Matthew Senjem has received stock or an ownership interest from LHC Group, Inc.. Matthew Senjem has received stock or an ownership interest from Natus Medical Incorporated. Matthew Senjem has received stock or an ownership interest from Varex Imaging Corporation. Matthew Senjem has received personal compensation in the range of $100,000-$499,999 for serving as a IT Technical Specialist II with Mayo Clinic. The institution of Dr. Jack has received research support from NIH. The institution of Dr. Jack has received research support from Alexander Family Alzheimer’s Disease Research Professorship of the Mayo Clinic. Dr. Lowe has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for AVID Radiopharmaceutical. Dr. Lowe has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai Inc. The institution of Dr. Lowe has received research support from AVID Radiopharmaceuticals. Dr. Josephs has nothing to disclose. Dr. Whitwell has nothing to disclose.
