文摘
摘要目的:关联MRI脑损伤在儿科临床结果anti-NMDA受体脑炎(pNMDARE)。
背景:据报道多达50%的核磁共振成像在NMDARE异常。然而,数据是有限的范围和类型的异常,以及如何pNMDARE异常核磁共振成像与结果。
设计/方法:这是一个与十机构多中心回顾性队列研究。NMDARE被定义为积极的CSF门冬氨酸受体抗体和至少一个神经精神症状。之前的HSV脑炎患者被排除在外。结果被改良Rankin评估分数(夫人)1年好夫人(≤2)与不良(≥3)夫人状况和全面复苏(夫人= 0)与不完全恢复(夫人> 0)。统计分析使用SAS 16.0(卡里,NC)。
结果:共有169名患者pNMDARE都包括,一年期夫人可在134/169 (79%)。异常核磁共振成像在59/169(35%),被发现的可能性,增加插管和入住ICU(卡方检验,p = 0.038, p = 0.045)。最常见的T2天赋病变位置是额(29/59,49%)、时间(28/59,47%),顶叶(19/59,32%),海马病变(11/59,19%)。MRI增强在34/165(21%)和MRI脑萎缩是4% (6/168)。核磁共振特性,预测不完全恢复在一年(夫人> 0)T2的存在额叶损伤(卡方检验,p = 0.0427)。G-tube位置和插管也预测不完全恢复。多变量逻辑回归分析使用逆向选择,一是与夫人:插管(或0.232,95% ci 0.103 - -0.526)和MRI T2额叶病灶(95%或0.373,0.148 - -0.938)。
结论:异常的正面病变MRI与插管可能在pNMDARE与一年期夫人。核磁共振成像为预测可能是一个有用的工具,将检查在将来的研究中。
披露:Gombolay博士的机构已经收到了研究中心的支持。Gombolay博士的机构收到NIH的研究支持。Brenton博士已经收到个人薪酬在500 - 4999美元的范围为在科学咨询服务或数据安全监测委员会周期药物。Brenton已收到博士研究的机构NIH /研究所的支持。Brenton博士已经收到个人薪酬在500 - 4999美元的范围作为格兰特与国防部的评论家。Brenton博士已经收到个人薪酬在500 - 4999美元的范围与MDEdge作为专家访谈。Brenton博士已经收到个人补偿的范围0 - 499美元与NIH担任格兰特评论家。杨医生已经收到个人薪酬在500 - 4999美元的范围在神经学活的演讲人。首页杨医生已经收到了来自曼联线粒体疾病的基础研究支持。Stredny博士的机构已收到研究小儿癫痫研究基金会的支持。 The institution of Dr. Kammeyer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genentech. The institution of Dr. Kammeyer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sanofi-Genzyme. Dr. Kammeyer has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Ogborn-Mihm Trial Lawyers. The institution of Dr. Kammeyer has received research support from Rocky Mountain Multiple Sclerosis Center. The institution of Dr. Otten has received research support from CDC. Dr. Vu has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Syneos Health. Dr. Santoro has received personal compensation for serving as an employee of UCB. Dr. Santoro has received personal compensation for serving as an employee of Cycle Pharma. Dr. ROBLES LOPEZ has nothing to disclose. Dr. Christiana has nothing to disclose. The institution of Dr. Steriade has received research support from NIH. The institution of Dr. Steriade has received research support from Dorris Duke Fund to Retain Clinician Scientists. Miss Morris has received personal compensation in the range of $10,000-$49,999 for serving as a Research Assistant/Specialist with Emory University, School of Medicine, Department of Pediatrics, Division of Neurology. The institution of Dr. Gorman has received research support from Pfizer. The institution of Dr. Gorman has received research support from Roche / Genetech . Dr. Moodley has nothing to disclose. Dr. Hardy has nothing to disclose. Dr. Kornbluh has nothing to disclose. Ilana Kahn has nothing to disclose. Dr. Sepeta has received personal compensation in the range of $500,000-$999,999 for serving as a Grant PI with Nih. Dr. Sepeta has a non-compensated relationship as a Special volunteer with Nih that is relevant to AAN interests or activities. Dr. Yeshokumar has nothing to disclose.
