文摘
摘要目的:探讨视网膜成像的效用与光学相干断层扫描血管造影(八面体)指标非侵入性小血管疾病的生物标志物和淀粉样蛋白在大脑中负担。
背景:八面体允许可视化和密度测量视网膜毛细血管各级。血管变化和淀粉样蛋白沉积与阿尔茨海默病(AD)和其它痴呆可能反映视网膜毛细血管密度的变化,使八面体侵入性小血管疾病的临床生物标志物和痴呆。
设计/方法:我们调查了八面体和神经影像学指标之间的关联在47个认知没有参与者的梅奥诊所研究衰老。八面体指标被用作预测,包括表面和深凹的毛细血管密度,parafovea,和黄斑中心凹无血管的区域从双眼的报道领域。神经影像学指标包括(负责人),高负担的白质高密度脑microbleeds,出现腔隙梗塞,而且存在的淀粉样蛋白沉积在正电子发射断层扫描(PET)就是明证。我们用线性模型来测试10月预测因子和神经影像学结果之间的联系而控制了年龄和性别。
结果:窝神经影像学指标之间的联系被限制,显示减少毛细血管密度增加的负担研究负责人在表面(p = 0.014)和深度(p = 0.013)凹但不是全部parafovea或斑点。同样,参与者与淀粉样蛋白沉积在表面毛细血管密度下降(p = 0.012)和深度(p = 0.015)窝而不是parafovea或斑点。参与者与淀粉样沉积也有明显大的《法兰克福汇报》(p = 0.029)。10月之间没有发现关联指标和存在脑microbleeds或腔隙梗塞的存在。
结论:视网膜中央凹毛细血管密度关联观察表明可能的常见疾病的机制之间的小血管疾病和阿尔茨海默病病理。
披露:贝穆德斯博士没有披露。盖Lesnick已收到个人赔偿作为梅奥诊所的一名雇员。博士更受到知识产权利益从发现或技术有关卫生保健。Ramanan博士没有披露。Knopman博士已经收到个人薪酬在5000 - 9999美元的范围为在科学咨询服务或数据安全监测委员会殿你研究。Knopman博士的机构收到NIH的研究支持。Vemuri博士已经收到个人薪酬在500 - 4999美元的范围为在演讲人米勒医疗服务通信公司. .Vemuri博士的机构收到NIH的研究支持。彼得森博士已经收到个人薪酬在500 - 4999美元的范围为罗氏公司担任顾问。彼得森博士已经收到个人薪酬在500 - 4999美元的范围为默克公司担任顾问。 Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genentech. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Nestle. Dr. Petersen has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genentech, Inc.. Dr. Petersen has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche, Inc.. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Graff-Radford has received personal compensation for serving as an employee of Mayo Clinic. Dr. Graff-Radford has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for NINDS/NIH. Dr. Graff-Radford has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for American Academy of Neurology. The institution of Dr. Graff-Radford has received research support from NIH. John J. Chen has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for UCB. John J. Chen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. John J. Chen has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Horizon.
