文摘
摘要目的:调查区域灰质(GM)之间的关联萎缩,神经递质分布和一大群患者的临床表现与多发性硬化(pwm)。
背景:在多发性硬化症(MS)、临床相关的通用萎缩进展以随机的方式,可能是由于优惠参与特定的神经网络,它尚未完全评估。
设计/方法:大脑3.0 T MRI扫描从286 pwm和172获得健康对照组(HC)。地区通用体积差异,地区通用萎缩和核imaging-derived神经递质之间的互关联地图和他们联系疾病持续时间、临床障碍、认知障碍、疲劳和抑郁研究使用分布形态测量学和Juspace工具箱。
结果:HC相比,pwm显示普遍cortico-subcortical通用萎缩与血清素激活的空间相关,多巴胺,阿片类药物,去,胆碱能和glutamatergic地图(错误发现率,(罗斯福)- p≤0.004)。pwm与疾病持续时间≥5 vs < 5年有一个重要的通用在几个深通用萎缩,皮质和小脑区域空间与较高的含血清素的分布和多巴胺受体(FDR-p≤0.03)。相比mildly-disabled pwm,那些扩展残疾状态量表(eds)≥3.0或≥4.0重要的大脑皮层,皮层下和小脑萎缩,与羟色胺和多巴胺的地图(FDR-p≤0.04)。很大空间通信与阿片类药物和胆碱能地图还发现与eds pwm≥4.0 vs < 4.0 (FDR-p≤0.04)。认知障碍与cognitively-preserved pwm有广泛的通用空间与血清素激活的萎缩,多巴胺,去甲,胆碱能和glutamatergic地图(FDR-p≤0.04)。pwm vs不疲劳有明显的皮质,皮层下和小脑萎缩,与羟色胺,多巴胺,阿片类药物和glutamatergic地图(FDR-p≥0.07)。没有明显的通用与神经递质萎缩和关联映射发现根据抑郁。
结论:通用萎缩地区属于特定的神经递质系统可能有助于解释临床表现女士的一部分,包括运动障碍、认知障碍和疲劳。
披露:Preziosa先生已经收到个人薪酬在500 - 4999美元的范围在百时美施贵宝公司的演讲人。Preziosa先生已经收到个人薪酬在500 - 4999美元的范围在赛诺菲Genzyme的演讲人。Preziosa先生已经收到个人薪酬在500 - 4999美元的范围在诺华的演讲人。Preziosa先生已经收到个人薪酬在500 - 4999美元的范围在罗氏的演讲人。Preziosa先生已经收到个人薪酬在500 - 4999美元的范围在默克的演讲人。菲奥雷博士没有披露。Tedone博士没有披露。莫妮卡Margoni接到MAGNIMS研究支持。卡门Vizzino没有披露。达米斯特里没有披露。 Dr. Gueye has nothing to disclose. Maria Assunta Rocca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Bristol Myers Squibb, Celgene, Genzyme, Merck Serono, Novartis, Roche, and Teva. The institution of Maria Assunta Rocca has received research support from Italian Ministry of Health, MS Society of Canada and Fondazione Italiana Sclerosi Multipla. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Bayer, Biogen Idec, Merck-Serono, Novartis, Roche, Sanofi Genzyme, Takeda, and Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Bayer, Biogen Idec, Merck-Serono, Novartis, Roche, Sanofi Genzyme, Takeda, and Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, Teva Pharmaceutical Industries, Italian Ministry of Health, Fondazione Italiana Sclerosi Multipla, and ARiSLA (Fondazione Italiana di Ricerca per la SLA).
