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To the Editor: We read with interest the article by Dayal et al. [1] on interferon gamma secreting cells in multiple sclerosis (MS) patients treated with interferon beta-1b. It is reported that the number of circulating interferon gamma-secreting cells are elevated shortly after the start of interferon beta treatment. This is a potentially important observation in view of the strong immunoregulatory role of interferon gamma. [2] This cytokine may, under certain circumstances, promote disease exacerbation in MS. …
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