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A specific isoform of apolipoprotein E (apoE) is associated with the accelerated rate of disease expression of sporadic Alzheimer's disease (AD) and late-onset familial AD. [1] It could be hypothesized that genetic variants affecting receptors for apoE-containing lipoproteins, if they exist, act as a potential risk factor for AD. An allelic association between the 5-repeat allele of a polymorphic triplet (CGG) repeat in the 5 prime-untranslated region of the gene for the very-low-density lipoprotein receptor (VLDL-R), a receptor for apoE-containing lipoproteins, and sporadic AD was reported; the 5-repeat allele and homozygotes for the 5-repeat allele were significantly frequent in Japanese sporadic AD patients than in Japanese control subjects. [2] …
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