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To the Editor: Payami et al. [1] recently claimed an increased risk of dementia of Alzheimer type (DAT) for female subjects in multiple affected pedigrees. This might be a specific feature of the examined population; however, this might also be a result of bias in family selection. Women tend to live longer than men. Consequently, demented female patients and relatives and pedigrees that include several affected women might be easier to recruit than their male counterparts. Thus, relative risk (RR) calculations might be biased as a result of selection and of the inclusion of affected index subjects (those who were first contacted). We had the opportunity to examine the influence of selection on …
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