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Reply from the Author: Reviews such as the one under discussion [1] are necessarily superficial. Eight printed pages are insufficient for an in-depth discussion of all aspects of spasticity including its pathophysiology and treatment; this was a review of spasticity, not of recurrent inhibition. Although only 1 of 16 paragraphs devoted to pathophysiology dealt with recurrent inhibition, considering neuroscience's superficial understanding of Renshaw cell activity in human spasticity, that seems a fair weighting of emphases. I encourage Drs. Mazzocchio and Rossi to prepare their own review of spasticity, emphasizing those aspects they believe appropriate for a broad neurologic audience.
As a neurophysiologist who first learned about Renshaw cells by monitoring their activity with microelectrodes in cat spinal cords, I have never been absolutely certain that the paired H-reflex technique, [4] drawing conclusions from which requires suspension of disbelief in a chain of hypotheses, can be relied on to measure recurrent inhibition, sensu stricto, either exclusively or predominantly. However, …
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