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To the Editor: We appreciated the report by Schwankhaus et al. [1] describing a family with hereditary adult-onset Alexander's disease. This report emphasizes the possible role of genetics in the different forms of Alexander's disease.
We contribute our case of an adult form of Alexander's disease previously reported. [2] We studied a 31-year-old woman who presented progressive dysautonomia, cerebellar ataxia, and pyramidal symptoms. CT showed pons, bulbar, and cerebellar atrophy. Postmortem examination demonstrated widespread Rosenthal's …
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