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March 01, 1999; 52 (5) Brief Communications

Neuroinvasion by human herpesvirus type 7 in a case of exanthem subitum with severe neurologic manifestations

J.S. P. van den Berg, J.H. van Zeijl, J.J. Rotteveel, W.J. G. Melchers, F.J. M. Gabreëls, J.M. D. Galama
First published March 1, 1999, DOI: https://doi.org/10.1212/WNL.52.5.1077
J.S. P. van den Berg
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J.H. van Zeijl
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J.J. Rotteveel
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W.J. G. Melchers
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F.J. M. Gabreëls
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J.M. D. Galama
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Citation
Neuroinvasion by human herpesvirus type 7 in a case of exanthem subitum with severe neurologic manifestations
J.S. P. van den Berg, J.H. van Zeijl, J.J. Rotteveel, W.J. G. Melchers, F.J. M. Gabreëls, J.M. D. Galama
Neurology Mar 1999, 52 (5) 1077; DOI: 10.1212/WNL.52.5.1077

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Abstract

Article abstract A 19-month-old girl presented with severe neurologic symptoms associated with exanthem subitum. Human herpesvirus type 7 (HHV-7) DNA was detected in the CSF and serum, and supported by serologic studies. The patient was diagnosed with encephalopathy due to an acute HHV-7 infection. Neuron-specific enolase in the CSF was strongly elevated during the acute stage of infection, suggesting that the encephalopathy was due to viral invasion of the brain.

  • Received September 1, 1998.
  • Accepted November 28, 1998.
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