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To the Editor:
As a neurologist with both clinical and research activities dealing with epilepsy, I read with interest the article by Arndt et al., “Outer retinal dysfunction in patients treated with vigabatrin.”1 The authors’ objective was to assess early visual impairment related to vigabatrin (VGB); in particular, the purpose of this study was to evaluate whether the electro-oculogram (EOG) might provide an additional diagnostic tool for screening visual functional impairment in patients treated by VGB alone or in association with other antiepileptic drugs (AED).
A complete clinical ophthalmologic and neurologic examination was performed on 20 patients with partial seizures. The patients treated had VGB for more than 6 months—alone or with carbamazepine (CBZ) or valproate (VPA). It is noteworthy that the history of patients’ antiepileptic therapy is not described, specifically the possibility of previous associations of VGB with other antiepileptic drugs. In light of the data, I challenge the authors’ report …
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