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July 12, 2000; 55 (1) Brief Communications

Cutaneous innervation in hereditary sensory and autonomic neuropathy type IV

L. Verzé, C. Viglietti–Panzica, L. Plumari, M. Calcagni, M. Stella, L.H. Schrama, G.C. Panzica
First published July 12, 2000, DOI: https://doi.org/10.1212/WNL.55.1.126
L. Verzé
From the Laboratory of Neuroendocrinology (Drs. VerzéViglietti–Panzica, and Panzica, and L. Plumari), Department of Anatomy, Pharmacology and Forensic Medicine, University of Torino, Italy; the Plastic Surgery Division and Burns Unit (Drs. Calcagni and Stella), CTO-CRF Maria Adelaide Hospital, Torino, Italy; and the Department of Medical Pharmacology (Dr. Schrama), Rudolf Magnus Institute for Neuroscience, Utrecht, The Netherlands.
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C. Viglietti–Panzica
From the Laboratory of Neuroendocrinology (Drs. VerzéViglietti–Panzica, and Panzica, and L. Plumari), Department of Anatomy, Pharmacology and Forensic Medicine, University of Torino, Italy; the Plastic Surgery Division and Burns Unit (Drs. Calcagni and Stella), CTO-CRF Maria Adelaide Hospital, Torino, Italy; and the Department of Medical Pharmacology (Dr. Schrama), Rudolf Magnus Institute for Neuroscience, Utrecht, The Netherlands.
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L. Plumari
From the Laboratory of Neuroendocrinology (Drs. VerzéViglietti–Panzica, and Panzica, and L. Plumari), Department of Anatomy, Pharmacology and Forensic Medicine, University of Torino, Italy; the Plastic Surgery Division and Burns Unit (Drs. Calcagni and Stella), CTO-CRF Maria Adelaide Hospital, Torino, Italy; and the Department of Medical Pharmacology (Dr. Schrama), Rudolf Magnus Institute for Neuroscience, Utrecht, The Netherlands.
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M. Calcagni
From the Laboratory of Neuroendocrinology (Drs. VerzéViglietti–Panzica, and Panzica, and L. Plumari), Department of Anatomy, Pharmacology and Forensic Medicine, University of Torino, Italy; the Plastic Surgery Division and Burns Unit (Drs. Calcagni and Stella), CTO-CRF Maria Adelaide Hospital, Torino, Italy; and the Department of Medical Pharmacology (Dr. Schrama), Rudolf Magnus Institute for Neuroscience, Utrecht, The Netherlands.
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M. Stella
From the Laboratory of Neuroendocrinology (Drs. VerzéViglietti–Panzica, and Panzica, and L. Plumari), Department of Anatomy, Pharmacology and Forensic Medicine, University of Torino, Italy; the Plastic Surgery Division and Burns Unit (Drs. Calcagni and Stella), CTO-CRF Maria Adelaide Hospital, Torino, Italy; and the Department of Medical Pharmacology (Dr. Schrama), Rudolf Magnus Institute for Neuroscience, Utrecht, The Netherlands.
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L.H. Schrama
From the Laboratory of Neuroendocrinology (Drs. VerzéViglietti–Panzica, and Panzica, and L. Plumari), Department of Anatomy, Pharmacology and Forensic Medicine, University of Torino, Italy; the Plastic Surgery Division and Burns Unit (Drs. Calcagni and Stella), CTO-CRF Maria Adelaide Hospital, Torino, Italy; and the Department of Medical Pharmacology (Dr. Schrama), Rudolf Magnus Institute for Neuroscience, Utrecht, The Netherlands.
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G.C. Panzica
From the Laboratory of Neuroendocrinology (Drs. VerzéViglietti–Panzica, and Panzica, and L. Plumari), Department of Anatomy, Pharmacology and Forensic Medicine, University of Torino, Italy; the Plastic Surgery Division and Burns Unit (Drs. Calcagni and Stella), CTO-CRF Maria Adelaide Hospital, Torino, Italy; and the Department of Medical Pharmacology (Dr. Schrama), Rudolf Magnus Institute for Neuroscience, Utrecht, The Netherlands.
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Citation
Cutaneous innervation in hereditary sensory and autonomic neuropathy type IV
L. Verzé, C. Viglietti–Panzica, L. Plumari, M. Calcagni, M. Stella, L.H. Schrama, G.C. Panzica
Neurology Jul 2000, 55 (1) 126-128; DOI: 10.1212/WNL.55.1.126

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Abstract

Article abstract The authors investigated immunocytochemically the innervation of a skin biopsy in a rare case of hereditary sensory and autonomic neuropathy type IV. A few protein gene product 9.5-, growth-associated protein 43-, calcitonin gene-related peptide-, and substance P-immunoreactive nerve fibers were observed in the deeper regions of the dermis. Neuropeptide Y-, nitric oxide-, and vasoactive intestinal polypeptide-immunoreactive fibers were completely absent. Their observations support the hypothesis that the sensory and autonomic defects reported in hereditary sensory and autonomic neuropathy are based on profound developmental alterations of the peripheral nervous system.

  • Received September 10, 1999.
  • Accepted in final form February 29, 2000.
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