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Epidemiologic studies, including studies of identical twins, argue for an infectious cause of MS. There is evidence that the pathogenesis of MS might involve an age-dependent host response to Epstein–Barr virus (EBV) infection, because an association between delayed primary infection and MS was shown.1 Recently, a serologically based association between clinical disease activity and EBV reactivation in MS was described.2 Although the absence of EBV DNA sequences in serum from patients with MS had been reported before, additional studies to delineate further the role of EBV in reactivation in MS are warranted. Here we present the results of a study using a unique set of clinical specimens: CSF and paraffin-embedded active demyelinating MS brain lesions obtained at autopsy and CSF from patients with MS and control subjects collected during life to assess the presence of EBV DNA in these clinical specimens by PCR.
Clinical material.
Formalin-fixed, paraffin-embedded brain tissue specimens obtained at rapid autopsy were collected …
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