This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Familial hemiplegic migraine (FHM) is an inheritable subset of migraine headache with motor paralysis. In 1996, gene mutations within the P/Q gated neuronal calcium channel α1A subunit (CACNA1A) were identified in patients with FHM.1 Subsequent genetic studies established multiple missense mutations in CACNA1A and genetic linkage to chromosomes 19p13 and 1q in various families with FHM.2-4⇓⇓ These findings suggest calcium channel dysfunction and implicate a role for calcium channel blockers in the treatment of hemiplegic migraine. We report a case of FHM and its abortive therapy with IV verapamil.
Case report.
A 28-year-old white woman had classic migraine headaches with visual aura since age 11. The headaches were throbbing in nature and accompanied by nausea and vomiting. They usually lasted for 3 to 4 hours and occurred every 4 to 5 months. However, during the past few months the patient started to have progressively …
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Topics Discussed
Alert Me
Recommended articles
Treatment of sporadic hemiplegic migraine with calcium-channel blocker verapamil
Clinical spectrum of hemiplegic migraine and chances of finding a pathogenic mutation
Child Neurology: Migraine with aura in children
Severe hemiplegic migraine attack precipitated by fentanyl sedation for esophagogastroscopy