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Dehydroepiandrosterone (DHEA), a weakly androgenic steroid secreted primarily by the adrenal cortex, is an intermediary in the biosynthesis of androgens and estrogens. Small quantities are produced within the brain.1 DHEA or its sulfate ester metabolite dehydroepiandrosterone sulfate (DHEAS) has been termed a superhormone in the popular press, on internet web sites, and in health food stores, as well as an “anti-aging hormone,” the “mother-of-all-hormones,” and the “fountain-of-youth hormone”—perhaps understandably. DHEAS is the most abundant circulating steroid, and drastic declines occur in serum and CSF levels with aging.2,3⇓ DHEA is advocated for cancer, heart disease, AIDS, obesity, diabetes, decreased libido, and Alzheimer’s disease (AD). Interest is particularly keen in the United States because DHEA is classified as a dietary supplement and can be purchased over the counter.
Putative effects of DHEA in AD involve DHEA/DHEAS directly, or they may be mediated through …
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