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Multiple Sclerosis: Immunology, Pathology, and Pathophysiology
edited by Robert M. Herndon,
239 pp., ill., New York, Demos Medical Publishing, 2003, $94.95
This multiauthored text by both pure scientists as well as clinician scientists is a companion to another recent text that addresses the clinical aspects of multiple sclerosis (MS) (Burks & Johnson) and together they represent a comprehensive review of this disease. The preface and introductory chapter from the editor highlight his tremendous experience both as a clinician and researcher and explain his bias as to the areas he has chosen to focus on throughout this text. The book is dedicated to three other MS clinician-scientists who, after devoting their careers to uncovering the secrets of this disease, recently died, leaving behind a legacy of trainees and researchers who are continuing their work, some of whom have contributed to this text. The editor demonstrates much of his own dedication to MS by authoring three major chapters.
The main focus is the pathogenesis of demyelination, describing in depth its pathology as well as the experimental and immunologic approaches to understanding how it might come about in the disease state. Appropriately, before one can understand demyelination, there is an excellent review of myelination leading from a discussion about the origin of oligodendrocytes, through active myelination, its morphology, and molecular structure. These chapters flow well with tables, drawings, micrographs, and ultrastructural electron microscopic photographs and so comprehensively cover the current field of knowledge that the reader is unlikely to need to look elsewhere for another review. The reference list alone for these three chapters is almost as valuable, citing over 400 key papers. The reader then needs to go to the latter part of the book for a discussion of MS-related pathology, which if anything suffers from a lack of being as thorough …
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