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To the Editor:
We read with interest the report by Lou et al. showing fatigue state in amyotrophic lateral sclerosis (ALS).1 The authors reported that patients with ALS scored high overall on the multidimensional fatigue inventory (MFI). In addition, patients with ALS had higher scores on generalized and physical measures than did controls. In their study, 44% of patients with ALS had depression. In our experience, about half of ALS cases exhibited depression. Depressive state and psychological state may influence the survival span in ALS, …
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