This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Common causes of chronic cough include infection, allergy, esophageal reflux, and treatment with ace inhibitors. Primary neurologic causes are rarely considered. Five patients were reported recently with chronic cough associated with Holmes-Adie syndrome (tonic pupils and areflexia).1 We describe a large family in whom chronic cough was associated with a Thr124 Met mutation in the MPZ gene.
Case report.
Proband.
A man aged 38 years had severe recurrent coughing spasms dating back to his late teens. These episodes could occur spontaneously or be triggered by noxious odors such as pepper or chlorine. Coughing spells were also induced when cleaning his ears with a cotton swab. The episodes would typically last for 20 to 30 minutes and end in retching and vomiting. He described these episodes as the “family curse” because several other family members had identical coughing spasms.
His mother observed his enlarged pupils as an infant, even in bright lights. In the fifth grade, he began regularly using over-the counter antacid medication for heartburn. In his mid-20s, …
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
