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June 22, 2004; 62 (12) Brief Communications

Doxycycline and intracranial hypertension

D. I. Friedman, L. K. Gordon, R. A. Egan, D. M. Jacobson, H. Pomeranz, A. R. Harrison, Y. Goldhammer
First published June 21, 2004, DOI: https://doi.org/10.1212/WNL.62.12.2297
D. I. Friedman
MD
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L. K. Gordon
MD PhD
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R. A. Egan
MD
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D. M. Jacobson
MD
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H. Pomeranz
MD PhD
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A. R. Harrison
MD
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Y. Goldhammer
MD
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Citation
Doxycycline and intracranial hypertension
D. I. Friedman, L. K. Gordon, R. A. Egan, D. M. Jacobson, H. Pomeranz, A. R. Harrison, Y. Goldhammer
Neurology Jun 2004, 62 (12) 2297-2299; DOI: 10.1212/WNL.62.12.2297

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Abstract

The authors report seven patients from six neuro-ophthalmology referral centers who developed pseudo-tumor cerebri during treatment with doxycycline. All four female patients and one of three male patients were obese. Vision was minimally affected in most patients, but two had substantial visual acuity or visual field loss at presentation. Discontinuation of doxycycline, with or without additional intracranial pressure-lowering agents, yielded improvement, but permanent visual acuity or visual field loss occurred in five patients.

  • Received October 8, 2003.
  • Accepted February 23, 2004.
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Letters: Rapid online correspondence

  • Doxycycline and intracranial hypertension
    • Alice Y.K. Chan, Department of Medicine & Therapeutics, the Chinese University of Hong Kong, Hong Kong, Department of Medicine & Therapeutics, 9/F, Professorial Block, Prince of Wales Hospital, Hong Kongalice_ykchan@yahoo.com.hk
    • David T.L. Liu
    Submitted September 27, 2004
  • Reply to Chan et al
    • Deborah I Friedman, University of Rocheter School of Medicine, 601 Elmwood Avenue, Box, 659, Rochester, NY 14642Deborah_Friedman@urmc.rochester.edu
    • Lynn K. Gordon, Robert A. Egan
    Submitted September 27, 2004
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