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April 13, 2004; 62 (7) Clinical/Scientific Notes

Neuralgic amyotrophy precipitated by Epstein–Barr virus

Bryan E. Tsao, Robin Avery, Robert W. Shields
First published April 12, 2004, DOI: https://doi.org/10.1212/01.WNL.0000118282.17433.31
Bryan E. Tsao
From the Section of Neuromuscular Disorders (Drs. Tsao and Shields), Department of Neurology, and Department of Infectious Diseases (Dr. Avery), Cleveland Clinic Foundation, OH.
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Robin Avery
From the Section of Neuromuscular Disorders (Drs. Tsao and Shields), Department of Neurology, and Department of Infectious Diseases (Dr. Avery), Cleveland Clinic Foundation, OH.
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Robert W. Shields
From the Section of Neuromuscular Disorders (Drs. Tsao and Shields), Department of Neurology, and Department of Infectious Diseases (Dr. Avery), Cleveland Clinic Foundation, OH.
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Citation
Neuralgic amyotrophy precipitated by Epstein–Barr virus
Bryan E. Tsao, Robin Avery, Robert W. Shields
Neurology Apr 2004, 62 (7) 1234-1235; DOI: 10.1212/01.WNL.0000118282.17433.31

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Neuralgic amyotrophy (NA), or Parsonage–Turner syndrome, is an uncommon idiopathic disorder that occurs on a sporadic or hereditary basis. We describe the clinical and electrodiagnostic (EDX) features of NA in two siblings with documented Epstein–Barr virus (EBV) infections. This raises the possibility that a common infection may trigger NA in family members who possess a genetic disposition to this disease.

Case reports.

Patient 1, a 20-year-old right-handed man, presented with fever, night sweats, and fatigue followed by aching pain in the right elbow and left shoulder. On day 11, he developed weakness in bilateral shoulder elevation, forearm pronation, right thumb flexion, right finger flexion, left wrist extension, and patchy sensory loss. The table contains laboratory and imaging results. IV solumedrol (900 mg/day for 3 days) did not provide relief. His weakness and pain continued to progress over 2 months, and a trial of IV immunoglobulin (IVIG; 400 mg/kg/day for 5 days) resulted in dramatic relief of pain. An EDX examination on day 62 showed evidence of severe to apparently complete …

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