This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Iron deficiency is important in the pathogenesis of restless legs syndrome (RLS), and iron supplementation improves its symptoms.1,2 Hereditary hemochromatosis (HH) is an autosomal recessive condition caused by mutations of the HFE gene in which excessive intestinal iron absorption leads to iron deposition in multiple organs.3 Iron therapy for RLS precipitated symptoms of iron overload in one patient with previously unrecognized HH,4 suggesting that monitoring of iron indexes may be required during iron therapy in RLS.
Methods.
We investigated the frequency of RLS and the relationship between RLS and iron indexes in consecutive adult patients with HH attending a large teaching hospital for therapeutic phlebotomy over a 3-month period. All 61 HH patients seen agreed to participate; 48 (79%) were men, and the median (range) age was 53 (24 to 82) years. The median (range) duration of phlebotomy was 12 (2 to 108) months, and 35 (62%) had serum ferritin level of <50 ng/mL. …
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
Letters: Rapid online correspondence
REQUIREMENTS
If you are uploading a letter concerning an article:
You must have updated your disclosures within six months: http://submit.neurology.org
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Use of Whole-Genome Sequencing for Mitochondrial Disease Diagnosis
Dr. Robert Pitceathly and Dr. William Macken