This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
We present a patient with adenocarcinoma of the lung, without CNS metastases, who developed progressive quadreparesis like that seen in the paraneoplastic syndrome acute necrotic myelopathy.1 Pathologic examination revealed only areas of brainstem and spinal cord demyelination resembling the acute lesions of multiple sclerosis (MS).
Case report.
A 66-year-old man was hospitalized after 4 weeks of persistent cough and 10 days of weakness and paresthesias of the legs. Over the next 5 days, his weakness progressed to paralysis of all extremities, dysphagia, and respiratory failure. He developed bilateral Babinski signs. Cognition and vision were unaffected and the sensory examination remained normal despite paresthesias. Chest CT scan revealed a hilar mass and abnormal masses in the liver and an adrenal gland, but biopsies of the hilar mass and the liver nodule were nondiagnostic. MRI of the brain and cervical spinal cord showed increased T2 signal in the medulla, extending into the upper cervical cord and a separate focus of T2 hyperintensity in the spinal cord …
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Topics Discussed
Alert Me
Recommended articles
Primary central nervous system vasculitis associated with lymphoma
Clinical Reasoning: Stepwise paralysis in a patient with adenocarcinoma of lung
Varicella-zoster virus vasculopathy
Targeted RNA Sequencing of Formalin-Fixed, Paraffin-Embedded Temporal Arteries From Giant Cell Arteritis Cases Reveals Viral Signatures