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October 25, 2005; 65 (8) Brief Communications

An open study of botulinum-A toxin treatment of trigeminal neuralgia

E. J. Piovesan, H. G. Teive, P. A. Kowacs, M. V. Della Coletta, L. C. Werneck, S. D. Silberstein
First published October 24, 2005, DOI: https://doi.org/10.1212/01.wnl.0000180940.98815.74
E. J. Piovesan
MD
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H. G. Teive
MD
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P. A. Kowacs
MD
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M. V. Della Coletta
MD
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L. C. Werneck
MD, PhD
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S. D. Silberstein
MD, FACP
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Citation
An open study of botulinum-A toxin treatment of trigeminal neuralgia
E. J. Piovesan, H. G. Teive, P. A. Kowacs, M. V. Della Coletta, L. C. Werneck, S. D. Silberstein
Neurology Oct 2005, 65 (8) 1306-1308; DOI: 10.1212/01.wnl.0000180940.98815.74

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Abstract

Thirteen subjects with trigeminal neuralgia were treated with botulinum-A neurotoxin (BoNT/A) in an open-label pilot study. After BoNT/A, visual analog scale score, surface area of pain, and therapeutic coefficient were reduced in all patients and for all branch trigeminal nerves studied. Therefore, BoNT/A is an efficient treatment. There were no major side effects. A placebo-controlled clinical trial is needed to confirm these findings.

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Letters: Rapid online correspondence

  • Reply from the Authors
    • Elcio Juliato Piovesan, Hospital de Clínicas da Universidade Federal do Parana, Rua General Carneiro - Curitiba, Paraná, Brazil[email protected]
    • H.G. Teive, P.A. Kowacs, M.V. Della Coletta, L.C. Werneck, S.D. Silbertein
    Submitted January 16, 2006
  • An open study of botulinum-A toxin treatment of trigeminal neuralgia
    • Joanna M. Zakrzewska, Barts and the London Queen Mary's School of Medicine and Dentistry, Turner Street, London E1 2AD, UNITED KINGDOM[email protected]
    • Jeffrey Cohen (New York, NY), Jeffrey Brown (Mineola, NY) , John Alksne (San Diego, CA), Henry Gemillion (Gainsville, FLA), Mark Linskey (Irvine CA), David Sirois (New York, NY) , Bruce Pollock (Rochester, MN)
    Submitted January 16, 2006
  • An open study of botulinum-A toxin treatment of trigeminal neuralgia
    • Bernhard Voller, Department of Neurology, Medical University of Vienna, Währingergürtel 18-20, A-1090 Wien, AUSTRIA[email protected]
    • Thomas Sycha, Burkhard Gustorff, Gottfried Kranz, and Eduard Auff
    Submitted January 16, 2006
  • An open study of botulinum-A toxin treatment of trigeminal neuralgia
    • Steven R Brenner, St.Louis VA Medical Center and St. Louis University Neurology Department, Dept. Neurology, St. Louis VA Med. Center, 915 North Grand, St. Louis, MO 63106[email protected]
    Submitted January 16, 2006
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