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July 25, 2006; 67 (2) Brief Communications

Sodium valproate vs phenytoin in status epilepticus: A pilot study

U. K. Misra, Jayantee Kalita, Rajesh Patel
First published July 24, 2006, DOI: https://doi.org/10.1212/01.wnl.0000224880.35053.26
U. K. Misra
DM
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Jayantee Kalita
DM
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Rajesh Patel
DM
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Citation
Sodium valproate vs phenytoin in status epilepticus: A pilot study
U. K. Misra, Jayantee Kalita, Rajesh Patel
Neurology Jul 2006, 67 (2) 340-342; DOI: 10.1212/01.wnl.0000224880.35053.26

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Abstract

Sixty-eight patients with convulsive status epilepticus (SE) were randomly assigned to two groups to study the efficacy of sodium valproate (VPA) and phenytoin (PHT). Seizures were aborted in 66% in the VPA group and 42% in the PHT group. As a second choice in refractory patients, VPA was effective in 79% and PHT was effective in 25%. The side effects in the two groups did not differ. Sodium valproate may be preferred in convulsive SE because of its higher efficacy.

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Letters: Rapid online correspondence

  • Sodium valproate vs phenytoin in status epilepticus: A pilot study
    • Andrea O. Rossetti, Service de Neurologie, CHUV BH-07, CH-1011-Lausanne, Switzerlandandrea.rossetti@chuv.ch
    Submitted September 19, 2006
  • Reply from the Authors
    • Usha Kant Misra, Professor & Head, Department of Neurology, Rae Bareily Road,Lucknow 226014, INDIAdrukmisra@rediffmail.com
    • Kalita, DM, R Patel, DM, Department of Neurology, Sanjay Gandhi PGIMS, Lucknow
    Submitted September 19, 2006
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