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Glufosinate ammonium (GLA), a phosphinic acid derivative of glutamate, is the active ingredient in commercial herbicides. GLA inhibits plant glutamine synthetase, leading to the complete inhibition of ammonia metabolism and photosynthesis. As the use of GLA-containing herbicides has increased, poisoning from incidental and suicidal ingestion has also increased. The neurologic complications of GLA intoxication are characterized by loss of consciousness, convulsions, or memory impairment.1 Unlike in plants, ammonia might not be involved in the toxicity of GLA in mammals2; however, the exact mechanism of GLA toxicity is unknown. Here, we report a patient with GLA poisoning who showed anterograde amnesia with selective bilateral hippocampal lesions and recovered behaviorally after 5 months.
Case report.
A 24-year-old1 man with no previous medical history presented to the emergency department 2 hours after accidentally drinking GLA. He was a college graduate and worked in factory. His friend reported that he probably mistook GLA for milk when he was drunk. Initially, he had recurrent nausea and vomiting. The vital signs were stable. An arterial blood gas determination …
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