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To the Editor:
Amato et al.1 compared cognitive and psychosocial functioning in a group of children and adolescents with multiple sclerosis (MS) to an age-matched cohort of healthy controls.
In the MS group, the prevalence of cognitive impairment was significant for 31% (failed three tests) of participants and minor for 53% (failed two tests). Patients with MS in the cognitively impaired group (n = 20) struggled in the areas of memory (especially visuospatial), complex attention, verbal comprehension, and executive functions.1 The authors did not report if any of the healthy controls failed two or more tests.
In agreement with some adult studies, the Expanded Disability Status Scale (EDSS) and the number of relapses were not adequate to predict cognitive status. In a multivariate logistic regression analysis that included age, sex, educational level, age at onset, number of relapses in the past 2 years, EDSS score, disease-modifying treatment, and IQ, only …
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