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Abstract
Objective: To determine whether alterations in cerebral blood flow regulation are associated with slow gait speed and falls in community-dwelling elderly individuals.
Methods: The study sample consisted of 419 individuals from the MOBILIZE Boston Study (MBS) who had transcranial Doppler ultrasound measures of cerebral blood flow velocity. The MBS is a prospective cohort study of a unique set of risk factors for falls in seniors in the Boston area. We measured beat-to-beat blood flow velocity in the middle cerebral artery in response to 1) changes in end-tidal CO2 (cerebral vasoreactivity) and 2) blood pressure changes during a sit-to-stand protocol (cerebral autoregulation). Gait speed was measured during a 4-meter walk. Falls were tracked by monthly calendars, and demographic and clinical characteristics were assessed at baseline.
Results: A multivariate linear regression analysis showed that cerebral vasoreactivity was cross-sectionally related to gait speed (p = 0.039). Individuals in the lowest quintile of vasoreactivity had lower gait speeds as compared to those in the highest quintile (p = 0.047). In a negative binomial regression analysis adjusted for relevant covariates, the relationship between cerebral vasoreactivity and fall rate did not reach significance. However, when comparing individuals in the lowest to highest quintile of cerebral vasoreactivity, those in the lowest quintile had a higher fall rate (p = 0.029).
Conclusions: Impaired cerebral blood flow regulation, as measured by cerebral vasoreactivity to CO2, is associated with slow gait speed and may lead to the development of falls in elderly people.
Glossary
- ACEI=
- angiotensin converting enzyme inhibitors;
- ADL=
- activities of daily living;
- ABP=
- arterial pressure monitoring;
- BFV=
- blood flow velocity;
- CES-D=
- Center for Epidemiologic Studies Depression Scale;
- CVR=
- cerebrovascular resistance;
- HR=
- heart rate;
- HVLT-R=
- Hopkins Verbal Learning Test–Revised;
- l-NMMA=
- l-NG-monomethyl arginine;
- MBS=
- MOBILIZE Boston Study;
- MCA=
- middle cerebral artery;
- SPPB=
- Short Physical Performance Battery;
- VR=
- vasoreactivity;
- WMSA=
- signal abnormalities in cerebral white matter.
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