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Abstract
Objective: We examined the development of Parkinson disease (PD)–mild cognitive impairment (MCI) in patients with newly diagnosed PD over 5 years using recently proposed consensus criteria, and we assessed the reliability of the criteria.
Methods: Patients with PD (n = 123) underwent extensive neuropsychological testing at baseline and after 3 (n = 93) and 5 years (n = 59). Two neuropsychologists independently applied the PD-MCI criteria to examine the interrater and intrarater reliability.
Results: At baseline, 35% of patients had PD-MCI. Three years later, 53% of the patients had PD-MCI. At 5-year follow-up, 20 patients who had PD-MCI at an earlier assessment had converted to PD dementia and 50% of the remaining patients without dementia had MCI. The interrater reliability (kappa) was 0.91. The intrarater reliabilities were 0.85 and 0.96.
Conclusion: Approximately one-third of patients with newly diagnosed PD fulfill the consensus criteria for PD-MCI; after 5 years, this proportion is approximately 50% of patients without dementia. The criteria have good interrater and intrarater reliability.
GLOSSARY
- AD=
- Alzheimer disease;
- CI=
- confidence interval;
- DSM-III-R=
- Diagnostic and Statistical Manual of Mental Disorders, 3rd edition, revised;
- FIM=
- Functional Independence Measure;
- H&Y=
- Hoehn & Yahr scale;
- HADS=
- Hospital Anxiety and Depression Scale;
- MCI=
- mild cognitive impairment;
- MMSE=
- Mini-Mental State Examination;
- mRCI=
- modified Reliable Change Index;
- PD=
- Parkinson disease;
- PDD=
- Parkinson disease dementia;
- PDQL=
- Parkinson's Disease Quality of Life;
- SE-ADL=
- Schwab and England Activities of Daily Living;
- UPDRS=
- Unified Parkinson’s Disease Rating Scale
Footnotes
Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
Supplemental data at www.neurology.org
- Received September 7, 2012.
- Accepted in final form April 10, 2013.
- © 2013 American Academy of Neurology
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