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August 20, 2013; 81 (8) Article

Cardiovascular disease and spinal cord injury

Results from a national population health survey

Jacquelyn J. Cragg, Vanessa K. Noonan, Andrei Krassioukov, Jaimie Borisoff
First published July 24, 2013, DOI: https://doi.org/10.1212/WNL.0b013e3182a1aa68
Jacquelyn J. Cragg
From the School of Population and Public Health, Faculty of Medicine (J.J.C.), International Collaboration on Repair Discoveries (ICORD) (J.J.C., A.K., J.B.), and Department of Medicine, Division of Physical Medicine and Rehabilitation (A.K.), University of British Columbia, Vancouver; Rick Hansen Institute (V.K.N.), Vancouver; GF Strong Rehabilitation Centre (A.K.), Vancouver Health Authority; and British Columbia Institute of Technology (BCIT) (J.B.), Burnaby, Canada.
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Vanessa K. Noonan
From the School of Population and Public Health, Faculty of Medicine (J.J.C.), International Collaboration on Repair Discoveries (ICORD) (J.J.C., A.K., J.B.), and Department of Medicine, Division of Physical Medicine and Rehabilitation (A.K.), University of British Columbia, Vancouver; Rick Hansen Institute (V.K.N.), Vancouver; GF Strong Rehabilitation Centre (A.K.), Vancouver Health Authority; and British Columbia Institute of Technology (BCIT) (J.B.), Burnaby, Canada.
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Andrei Krassioukov
From the School of Population and Public Health, Faculty of Medicine (J.J.C.), International Collaboration on Repair Discoveries (ICORD) (J.J.C., A.K., J.B.), and Department of Medicine, Division of Physical Medicine and Rehabilitation (A.K.), University of British Columbia, Vancouver; Rick Hansen Institute (V.K.N.), Vancouver; GF Strong Rehabilitation Centre (A.K.), Vancouver Health Authority; and British Columbia Institute of Technology (BCIT) (J.B.), Burnaby, Canada.
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Jaimie Borisoff
From the School of Population and Public Health, Faculty of Medicine (J.J.C.), International Collaboration on Repair Discoveries (ICORD) (J.J.C., A.K., J.B.), and Department of Medicine, Division of Physical Medicine and Rehabilitation (A.K.), University of British Columbia, Vancouver; Rick Hansen Institute (V.K.N.), Vancouver; GF Strong Rehabilitation Centre (A.K.), Vancouver Health Authority; and British Columbia Institute of Technology (BCIT) (J.B.), Burnaby, Canada.
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Citation
Cardiovascular disease and spinal cord injury
Results from a national population health survey
Jacquelyn J. Cragg, Vanessa K. Noonan, Andrei Krassioukov, Jaimie Borisoff
Neurology Aug 2013, 81 (8) 723-728; DOI: 10.1212/WNL.0b013e3182a1aa68

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Abstract

Objective: To evaluate the association between cardiovascular disease (CVD) and spinal cord injury (SCI) in a large representative sample.

Methods: Data were compiled from more than 60,000 individuals from the 2010 cycle of the cross-sectional Canadian Community Health Survey (CCHS). Multivariable logistic regression analysis was conducted to examine this relationship, adjusting for confounders and using probability weighting to account for the CCHS sampling method.

Results: After adjusting for age and sex, SCI was associated with a significant increased odds of heart disease (adjusted odds ratio [OR] = 2.72, 95% confidence interval [CI] 1.94–3.82) and stroke (adjusted OR = 3.72, 95% CI 2.22–6.23).

Conclusions: These remarkably heightened odds highlight the exigent need for targeted interventions and prevention strategies addressing modifiable risk factors for CVD in individuals with SCI.

GLOSSARY

CCHS=
Canadian Community Health Survey;
CI=
confidence interval;
CVD=
cardiovascular disease;
MI=
myocardial infarction;
OR=
odds ratio;
SCI=
spinal cord injury

Footnotes

  • Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • Editorial, page 700

  • Received December 2, 2012.
  • Accepted in final form April 22, 2013.
  • © 2013 American Academy of Neurology
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