March 25, 2014; 82 (12) Article
Comorbidity and medication in REM sleep behavior disorder
A multicenter case-control study
Birgit Frauscher, Poul Jennum, Yo-El S. Ju, Ronald B. Postuma, Isabelle Arnulf, Valerie Cochen De Cock, Yves Dauvilliers, Maria L. Fantini, Luigi Ferini-Strambi, David Gabelia, Alex Iranzo, Smaranda Leu-Semenescu, Thomas Mitterling, Masayuki Miyamoto, Tomoyuki Miyamoto, Jacques Y. Montplaisir, Wolfgang Oertel, Amélie Pelletier, Paolo Prunetti, Monica Puligheddu, Joan Santamaria, Karel Sonka, Marcus Unger, Christina Wolfson, Marco Zucconi, Michele Terzaghi, Birgit Högl, Geert Mayer, Raffaele Manni
First published February 19, 2014, DOI: https://doi.org/10.1212/WNL.0000000000000247
Birgit Frauscher
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MDPoul Jennum
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MDYo-El S. Ju
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MDRonald B. Postuma
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MD, MScIsabelle Arnulf
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MD, PhDValerie Cochen De Cock
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MD, PhDYves Dauvilliers
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MD, PhDMaria L. Fantini
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MD, MScLuigi Ferini-Strambi
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MDDavid Gabelia
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MDAlex Iranzo
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MDSmaranda Leu-Semenescu
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MDThomas Mitterling
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MDMasayuki Miyamoto
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MD, PhDTomoyuki Miyamoto
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MD, PhDJacques Y. Montplaisir
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MD, PhDWolfgang Oertel
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MDAmélie Pelletier
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
PhDPaolo Prunetti
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MDMonica Puligheddu
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MDJoan Santamaria
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MDKarel Sonka
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MD, PhDMarcus Unger
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MDChristina Wolfson
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
PhDMarco Zucconi
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MDMichele Terzaghi
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MDBirgit Högl
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MDGeert Mayer
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MDRaffaele Manni
From the Department of Neurology (B.F., D.G., T.M., B.H.), Innsbruck Medical University, Austria; Danish Center for Sleep Medicine (P.J.), University of Copenhagen, Denmark; Department of Neurology (Y.-E.S.J.), Washington University School of Medicine, St Louis, MO; Department of Neurology (R.B.P.), McGill University, Montreal General Hospital, Canada; Unité des Pathologies du Sommeil (I.A., S.L.-S.), Hôpital Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University, Paris; Sleep Unit (V.C.D.C., Y.D.), Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061, Montpellier, France; Sleep Disorders Center (M.L.F.), Department of Neurosciences, University of Turin, Italy; UFR Medecine (M.L.F.), EA 7280, University Clermont 1, France; Sleep Disorders Center (L.F.-S., M.Z.), Università Vita-Salute San Raffaele, Milan, Italy; Neurology Service (A.I., J.S.), Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Spain; Department of Neurology (M.M.), Dokkyo Medical University School of Medicine, Tochigi; Department of Neurology (T.M.), Dokkyo Medical University Koshigaya Hospital, Saitama, Japan; Centre d'Études Avancées en Médecine du Sommeil (J.Y.M.), Hôpital du Sacré-Coeur de Montréal, Canada; Philipps-Universität (W.O., M.U.), Marburg, Germany; Neuroepidemiology Research Unit (A.P., C.W.), Research Institute of the McGill University Health Centre, Montreal; Canada; Unit of Sleep Medicine (P.P., M.T., R.M.), National Institute of Neurology IRCCS, C. Mondino Foundation, Pavia; Sleep Center (M.P.), Department of Cardiovascular and Neurological Sciences, University of Cagliari, Italy; Department of Neurology (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Neurology (M.U.), Saarland University, Homburg/Saar; and Hephata Klinik (G.M.), Schwalmstadt-Treysa, Germany.
MDComorbidity and medication in REM sleep behavior disorder
A multicenter case-control study
Birgit Frauscher, Poul Jennum, Yo-El S. Ju, Ronald B. Postuma, Isabelle Arnulf, Valerie Cochen De Cock, Yves Dauvilliers, Maria L. Fantini, Luigi Ferini-Strambi, David Gabelia, Alex Iranzo, Smaranda Leu-Semenescu, Thomas Mitterling, Masayuki Miyamoto, Tomoyuki Miyamoto, Jacques Y. Montplaisir, Wolfgang Oertel, Amélie Pelletier, Paolo Prunetti, Monica Puligheddu, Joan Santamaria, Karel Sonka, Marcus Unger, Christina Wolfson, Marco Zucconi, Michele Terzaghi, Birgit Högl, Geert Mayer, Raffaele Manni
Neurology Mar 2014, 82 (12) 1076-1079; DOI: 10.1212/WNL.0000000000000247
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Abstract
Objective: This controlled study investigated associations between comorbidity and medication in patients with polysomnographically confirmed idiopathic REM sleep behavior disorder (iRBD), using a large multicenter clinic-based cohort.
Methods: Data of a self-administered questionnaire on comorbidity and medication use of 318 patients with iRBD and 318 matched controls were analyzed. Comparisons between cases and controls were made using logistic regression analysis.
Results: Patients with iRBD were more likely to report depression (odds ratio [OR] 2.0, 95% confidence interval [CI] 1.3–2.9) and concomitant antidepressant use (OR 2.2, 95% CI 1.4–3.6). Subanalysis of antidepressant agents revealed that the increased use of antidepressants in iRBD was due to selective serotoninergic reuptake inhibitors (OR 3.6, 95% CI 1.8–7.0) and not due to other antidepressant classes. Patients with iRBD reported more lifetime antidepressant use than comorbid depression (antidepressant use: OR 1.9, 95% CI 1.1–3.3; depression: OR 1.6, 95% CI 1.0–2.5). Patients with iRBD reported more ischemic heart disease (OR 1.9, 95% CI 1.1–3.1). This association did not change substantially when adjusting for cardiovascular risk factors (OR 2.3, 95% CI 1.3–3.9). The use of inhaled glucocorticoids was higher in patients with iRBD compared to controls (OR 5.3, 95% CI 1.8–15.8), likely reflecting the higher smoking rate in iRBD (smoking: OR 15.3, 95% CI 2.0–118.8; nonsmoking: OR 2.4, 95% CI 0.4–13.2) and consequent pulmonary disease.
Conclusions: This large study confirms the association between comorbid depression and antidepressant use in iRBD. In addition, there was an unexpected association of iRBD with ischemic heart disease that was not explained by cardiovascular risk factors.
GLOSSARY
- CI=
- confidence interval;
- iRBD=
- idiopathic REM sleep behavior disorder;
- IRBDSG=
- International RBD Study Group;
- OR=
- odds ratio;
- RBD=
- REM sleep behavior disorder;
- SA=
- sleep apnea
Footnotes
↵* These authors contributed equally to this work.
Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
Supplemental data at Neurology.org
- Received August 8, 2013.
- Accepted in final form December 13, 2013.
- © 2014 American Academy of Neurology
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