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Central neurogenic hyperventilation (CNH) is a rare neurologic condition that develops secondary to brainstem involvement. Approximately 35 noncomatose patients with CNH have been reported, including 7 with either a diffuse (patients 2–10 in the table) or focal (patient 1 in the table) brainstem glioma.1–7 Although diffuse intrinsic pontine glioma (DIPG) is the most common pediatric brainstem cancer, only one case report described a child with DIPG who experienced CNH.6
Footnotes
Supplemental data at Neurology.org
Author contributions: Davonna Ledet reviewed and analyzed the data, drafted the manuscript for content, and approved the final version of this manuscript. Noel M. Delos Santos analyzed the data, revised the manuscript for content, and approved the final version of this manuscript. Raja Khan revised the manuscript for content and approved the final version of this manuscript. Amar Gajjar provided patients for this study, revised the manuscript for content, and approved the final version of this manuscript. Alberto Broniscer designed and provided patients for this study, analyzed the data, drafted and revised the manuscript for content, and approved the final version of this manuscript.
Study funding: Supported by the United States NIH Cancer Center Support (CORE) Grant P30 CA21765 and by the American Lebanese Syrian Associated Charities (ALSAC).
Disclosure: The authors report no disclosures relevant to the manuscript. Go to Neurology.org for full disclosures.
- Received September 26, 2013.
- Accepted in final form December 4, 2013.
- © 2014 American Academy of Neurology
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