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Primary CNS lymphoma (PCNSL), a type of extranodal non-Hodgkin lymphoma, is a potentially curable brain cancer. Ongoing randomized trials assessing treatments for PCNSL will ultimately establish a standard of care. Until that time, practitioners have multiple treatment options from which to choose. In this report, the authors provide long-term follow-up data from a phase 2 clinical trial in newly diagnosed PCNSL patients, ages 18–70, treated with MATILDE chemotherapy followed by whole-brain radiation therapy (WBRT).1 The MATILDE regimen, like all induction chemotherapy currently utilized for PCNSL, includes methotrexate, the single most effective agent against PCNSL. Following chemotherapy, patients received a consolidative WBRT dose based on their initial response to chemotherapy.
Footnotes
Study funding: No targeted funding reported.
Disclosure: T. Batchelor serves as a consultant or in an advisory role for Merck & Co., Inc., Roche, Kirin Pharmaceuticals, Spectrum, Champions Biotechnology, Advance Medical, Novartis, and Agenus; has received honoraria from Up to Date, Inc., Robert Michael Educational Institute LLC, Educational Concepts Group, Research to Practice, Imedex, Oakstone Medical Publishing, and American Society of Hematology; and receives research support from Pfizer, Astra Zeneca, Millennium, and NIH. Go to Neurology.org for full disclosures.
- © 2014 American Academy of Neurology
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