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The association between overt hypothyroidism and atherosclerotic risk factors, especially hypertension and dyslipidemia, is clear. To date, only a few small and methodologically flawed epidemiologic studies have investigated the relationship between hypothyroidism and stroke, precluding definitive conclusions. In the current issue of Neurology®, Karch and Thomas1 present a large well-designed case-control study investigating this relationship. They compared 34,907 patients with autoimmune thyroiditis on treatment with l-thyroxine and 149,632 matched individuals without autoimmune thyroiditis from a UK primary care electronic health record system. They found a slight increase in the risk of stroke in patients with autoimmune thyroiditis (adjusted relative risk = 1.10, 95% confidence interval: 1.01–1.20) compared with controls. Some of this increased risk of stroke was independent of cardiovascular risk factors.
Footnotes
Study funding: No targeted funding reported.
Disclosure: The authors report no disclosures. Go to Neurology.org for full disclosures.
- © 2014 American Academy of Neurology
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