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Immunoglobulin G4–related diseases (IgG4-RD) are a newly recognized category of diseases. CNS involvement in IgG4-RD includes hypophysitis1 and intracranial or spinal manifestations of hypertrophic pachymeningitis.2,3 We present a unique case of rapid cognitive decline due to IgG4-related leptomeningitis.
Acknowledgments
Acknowledgment: The authors thank movement disorders fellows Drs. Daniel Dees and Jill Trumble for assisting with the production of the video of the patient.
Footnotes
↵* These authors contributed equally to this work.
Supplemental data at www.neurology.org
Author contributions: S.H.M.: drafting/revising the manuscript for content, analysis/interpretation of data. J.A.S.: drafting/revising the manuscript for content, analysis/interpretation of data. P.B.: drafting/revising the manuscript for content, analysis/interpretation of data. A.M.R.: drafting/revising the manuscript for content, analysis/interpretation of data.
Study funding: No targeted funding reported.
Disclosure: S. Mehta reports no disclosures. J. Switzer has consulted for Genentech and REACH Health, Inc., and receives research support from Genentech and the American Heart Association. P. Biddinger and A. Rojiani report no disclosures. Go to Neurology.org for full disclosures.
- Received May 29, 2013.
- Accepted in final form October 1, 2013.
- © 2014 American Academy of Neurology
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