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Antiphospholipid syndrome (APS) is a rare autoimmune coagulopathy with various systemic and neurologic symptoms. Ischemic stroke and TIA are common neurologic manifestations of APS, while migraine, epilepsy, chorea, and multiple sclerosis–like syndromes have also been reported.1,2 Dementia is an unusual manifestation of APS, and the presentation of APS with corticobasal syndrome (CBS) has rarely been reported.3,4 CBS is a progressive neurologic syndrome characterized by asymmetric cortical dysfunction such as apraxia, alien limb phenomenon, or cortical sensory changes accompanied by akineto-rigid syndrome or dystonia.5,6 Cognitive dysfunction is not uncommon in this disease. The underlying pathologies of CBS, which include corticobasal degeneration (CBD), Alzheimer disease, Pick disease, progressive supranuclear palsy, Lewy body dementia, Creutzfeldt-Jakob disease, motor neuron inclusion body dementia, and dementia lacking distinctive histopathology, are heterogeneous.5,6 Herein, we discuss a patient with APS who presented with CBS.
Footnotes
Author contributions: Dong-Won Lee: drafting/revising the manuscript for content, analysis or interpretation of data. Si-Won Eum: analysis or interpretation of data. Chan O. Moon: analysis or interpretation of data. Hyeo-Il Ma: study concept or design, analysis or interpretation of data. Yun Joong Kim: drafting/revising the manuscript for content, study concept or design, analysis or interpretation of data.
Study funding: No targeted funding reported.
Disclosure: The authors report no disclosures relevant to the manuscript. Go to Neurology.org for full disclosures.
- Received August 26, 2013.
- Accepted in final form October 14, 2013.
- © 2014 American Academy of Neurology
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