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September 23, 2014; 83 (13) Article

Long-term increased risk of unemployment after young stroke

A long-term follow-up study

Noortje A.M.M. Maaijwee, Loes C.A. Rutten-Jacobs, Renate M. Arntz, Pauline Schaapsmeerders, Hennie C. Schoonderwaldt, Ewoud J. van Dijk, Frank-Erik de Leeuw
First published August 15, 2014, DOI: https://doi.org/10.1212/WNL.0000000000000817
Noortje A.M.M. Maaijwee
From the Department of Neurology, Centre for Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, the Netherlands. L.C.A.R.-J. is currently with the Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
MD
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Loes C.A. Rutten-Jacobs
From the Department of Neurology, Centre for Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, the Netherlands. L.C.A.R.-J. is currently with the Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
PhD
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Renate M. Arntz
From the Department of Neurology, Centre for Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, the Netherlands. L.C.A.R.-J. is currently with the Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
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Pauline Schaapsmeerders
From the Department of Neurology, Centre for Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, the Netherlands. L.C.A.R.-J. is currently with the Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
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Hennie C. Schoonderwaldt
From the Department of Neurology, Centre for Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, the Netherlands. L.C.A.R.-J. is currently with the Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
MD, PhD
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Ewoud J. van Dijk
From the Department of Neurology, Centre for Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, the Netherlands. L.C.A.R.-J. is currently with the Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
MD, PhD
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Frank-Erik de Leeuw
From the Department of Neurology, Centre for Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, the Netherlands. L.C.A.R.-J. is currently with the Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
MD, PhD
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Citation
Long-term increased risk of unemployment after young stroke
A long-term follow-up study
Noortje A.M.M. Maaijwee, Loes C.A. Rutten-Jacobs, Renate M. Arntz, Pauline Schaapsmeerders, Hennie C. Schoonderwaldt, Ewoud J. van Dijk, Frank-Erik de Leeuw
Neurology Sep 2014, 83 (13) 1132-1138; DOI: 10.1212/WNL.0000000000000817

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Abstract

Objective: To investigate the prevalence, excess risk, and risk factors of unemployment in patients after a TIA, ischemic stroke, or intracerebral hemorrhage at ages 18 through 50 years, compared with nationwide controls.

Methods: We performed a hospital-based cohort study among 694 patients, aged 18–50 years, with a first-ever TIA, ischemic stroke, or intracerebral hemorrhage. After a mean follow-up duration of 8.1 (SD 7.7) years, we used logistic regression analysis to calculate odds ratio (OR) with 95% confidence interval (CI) for being unemployed as a young stroke patient, compared with the Dutch population of vocational age (n = 7,803,000), with subsequent assessment of risk factors of unemployment.

Results: Young stroke patients had a higher risk of being unemployed than their peers in the Dutch population: women OR 2.3 (1.8–2.9), men OR 3.2 (2.5–4.0). A higher NIH Stroke Scale score at admission (OR 1.1 [95% CI 1.0–1.1]) and a longer follow-up duration (middle tertile OR 2.8 [95% CI 1.7–4.7], upper tertile OR 3.4 [95% CI 1.9–6.1]) were associated with a higher risk of being unemployed.

Conclusion: Young stroke patients had a 2–3 times higher risk of unemployment after 8 years of follow-up. Return-to-work programs should be developed, adjusted, and evaluated in order to diminish the negative effects that unemployment can have on patients' life satisfaction and to limit the socioeconomic consequences.

GLOSSARY

CBS=
Central Bureau of Statistics;
CI=
confidence interval;
FUTURE=
Follow-Up of TIA and stroke patients and Unelucidated Risk factor Evaluation;
ICH=
intracerebral hemorrhage;
NIHSS=
NIH Stroke Scale;
OR=
odds ratio

Footnotes

  • Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • Editorial, page 1128

  • Supplemental data at Neurology.org

  • Received January 7, 2014.
  • Accepted in final form May 23, 2014.
  • © 2014 American Academy of Neurology
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