定量成像生物标记后的脑水肿23 (percnt)盐水肝功能衰竭(P6.035)

文摘

目的:我们研究的假设丸23.4 (percnt)高渗盐水(高温超导)减少脑水肿严重肝性脑病患者使用无创定量技术来测量大脑和脑脊液体积变化。背景:脑水肿是常见的严重肝性脑病和可能危及生命。丸23.4 [percnt]高温超导提高监测neuromonitoring分数,尽管它的作用机制并不明确。此外,侵入颅内监测在严重肝性脑病的管理是有争议的。无创定量测量脑水肿可能是临床上有用的。设计/方法:我们回顾性严重肝性脑病患者接受23.4 (percnt)高温超导和控制患者没有收到23.4 (percnt)高温超导。我们使用获得的临床CT扫描测量心室的体积,颅内脑脊液和大脑使用之前验证自动化技术(分析直接;Overland Park, KS)。卷23.4前后(percnt)高温超导与符号秩检验进行比较。CSF总额之间的关联、心室体积和血清钠使用斯皮尔曼相关评估。 RESULTS: Ten patients with 17 administrations of 23.4[percnt] HTS met inclusion criteria. Total CSF (median 46.9 [IQR 34.7-65.7] to 61.2 [IQR 47.2-79.9] mL, p<0.001) and ventricular (median 7.9 [IQR 6.9-9.4] to 9.0 [IQR 7.8-11.5] mL, p=0.003) volumes increased and Glasgow Coma Scale Scores improved after 23.4[percnt] HTS. In contrast, total CSF and ventricular volumes decreased in matched, untreated control patients. Serum sodium increase was associated with increase in total CSF volume (r=0.81, p<0.001) and change in total CSF volume was associated with ventricular volume change (r=0.85, p<0.001). CONCLUSIONS: Total CSF and ventricular volumes increased after 23.4[percnt] HTS, consistent with a reduction in parenchymal edema. Total CSF and ventricular volume change may be useful quantitative biomarkers to assess cerebral edema. Study Supported by: department funds

披露:李欧塔博士没有披露。Lizza博士没有披露。Romanova博士没有披露。古思博士没有披露。伯曼博士没有披露。卡罗尔博士没有披露。工头博士没有披露。拉博士没有披露。弗朗西斯博士没有披露。马斯博士没有披露。 Dr. Naidech has received research support from Gaymar Inc.