基于证据的指南:成人无端首次癫痫发作的管理

Cumulative proportion of patients experiencing a seizure recurrence after randomization, comparing immediate vs deferred treatment Cumulative proportion of patients with an unprovoked first seizure experiencing a seizure recurrence after randomization and comparing patients with immediate antiepileptic drug treatment vs patients with treatment deferred pending a seizure recurrence (A), and in this specific study, comparing those individuals with patients who had multiple seizures before randomization to treatment (B). Reprinted from The Lancet (Marson et al. Immediate versus deferred antiepileptic drug treatment for early epilepsy and single seizures: a randomised controlled trial. Lancet 2005;365:2007–2013), © 2005, with permission from Elsevier.¹⁵