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Impaired consciousness, ascribed to injury of the ascending reticular activating system (ARAS), is a serious clinical manifestation of hypoxic-ischemic brain injury (HI-BI). Many patients with HI-BI remain in an impaired state of arousal (e.g., persistent vegetative or a minimally conscious state).1 Diffusion tensor tractography (DTT), derived from diffusion tensor imaging (DTI), enables 3D reconstruction and approximation of the ARAS in the human brain.2–5 Although recent studies using DTT reported ARAS injury in patients with brain injury (e.g., traumatic brain injury and HI-BI),5,6 little is known about ARAS recovery in patients with brain injury. Here, using DTT, we report on a patient with HI-BI with ARAS recovery.
Footnotes
Author contributions: Sung Ho Jang: study concept and design, manuscript development and writing. Han do Lee: study concept and design, acquisition and analysis of data, manuscript authorization.
Study funding: Supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012R1A1A4A01001873).
Disclosure: The authors report no disclosures relevant to the manuscript. Go to Neurology.org for full disclosures.
- Received October 14, 2014.
- Accepted in final form January 7, 2015.
- © 2015 American Academy of Neurology
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