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June 09, 2015; 84 (23) Editorial

Understanding the comparative effectiveness of treatment in pediatric epilepsy

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Douglas R. Nordli, Jyun-You Liou
First published May 6, 2015, DOI: https://doi.org/10.1212/WNL.0000000000001672
Douglas R. Nordli
From the Epilepsy Center, Anne & Robert H. Lurie Children's Hospital of Chicago, IL.
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Jyun-You Liou
From the Epilepsy Center, Anne & Robert H. Lurie Children's Hospital of Chicago, IL.
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Understanding the comparative effectiveness of treatment in pediatric epilepsy
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Douglas R. Nordli, Jyun-You Liou
Neurology Jun 2015, 84 (23) 2298-2299; DOI: 10.1212/WNL.0000000000001672

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In this issue of Neurology®, Jung et al.1 present the results of a thoughtful prospective study examining the neuropsychological findings in children treated with 2 medications commonly used for the treatment of focal seizures, levetiracetam and carbamazepine. Their study followed 81 children with focal epilepsy, randomized to either treatment, for 1 year. They found levetiracetam is non-inferior in efficacy and tolerability compared to carbamazepine. In addition, there was no difference in neuropsychological testing performed at baseline and at the end of the study. Both aspects of this study are noteworthy.

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  • Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the editorial.

  • See page 2312

  • © 2015 American Academy of Neurology
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