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Abstract
Objective: To identify early prognostic factors of relapse and disability in children presenting with an acute idiopathic transverse myelitis (TM).
Methods: Ninety-five children with acute idiopathic TM from 2 national European cohorts (France and United Kingdom) of CNS demyelinating diseases in children were identified and studied for early factors that predict relapse and disability using logistic regression models.
Results: Sixteen (17%) relapsed, with a diagnosis of multiple sclerosis in 13 (14%) and neuromyelitis optica in 3 (3%). Logistic regression revealed 2 main criteria as risk factors for relapse: female sex (odds ratio [OR] 3.21, 95% confidence interval [CI] 0.88–11.78) and presence of associated brain lesions (OR 14.0, 95% CI 2.8–69.3). Twenty-eight (30%) children had a poor outcome defined by a Kurtzke Expanded Disability Status Scale score ≥4 or an American Spinal Injury Association impairment (ASIA) scale <D at last follow-up. Five factors were associated with poor outcome: female sex (OR 5.8, 95% CI 0.99–32.7), severe ASIA scale at onset (OR 33.5, 95% CI 1.8–618), gadolinium enhancement on spinal MRI (OR 24.1, 95% CI 3.78–153.88), absence of pleocytosis (OR 4.6, 95% CI 0.87–26.0), and absence of cervical or cervico-thoracic lesion on spinal MRI (OR 3.9, 95% CI 0.78–19.6).
Conclusions Early predictors of relapse and disability identified in this large childhood study of acute idiopathic TM have important utility for clinical management. Larger prospective collaborative studies are required to validate these findings, which may improve the design of clinical trials.
GLOSSARY
- ASIA=
- American Spinal Injury Association;
- CI=
- confidence interval;
- EDSS=
- Expanded Disability Status Scale;
- GO=
- good outcome;
- HSV=
- herpes simplex virus;
- IPMSSG=
- International Pediatric Multiple Sclerosis Study Group;
- MS=
- multiple sclerosis;
- NMO=
- neuromyelitis optica;
- OR=
- odds ratio;
- PO=
- poor outcome;
- ROC=
- receiver operating characteristic;
- TM=
- transverse myelitis;
- TMCWG=
- Transverse Myelitis Consortium Working Group
Footnotes
↵* These authors contributed equally to this work.
↵‡ Joint senior authors.
Coinvestigators are listed on the Neurology® Web site at Neurology.org.
Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
Editorial, page 332
Supplemental data at Neurology.org
- Received February 21, 2014.
- Accepted in final form August 8, 2014.
- © 2014 American Academy of Neurology
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