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Between 25% and 50% of patients with Parkinson disease (PD) develop mild cognitive impairment (MCI) or dementia within 5 years of their diagnosis.1,2 Until the study by Pigott et al.3 in this issue of Neurology®, few studies had identified patients with PD with normal cognition at baseline and followed them prospectively to find the rate of cognitive decline and the clinical predictors for that decline. They found that the development of cognitive impairment was “common and relatively quick,” with the cumulative incidence of 8.5% cognitive impairment at year 1 and 47.4% at year 6. While it is often difficult to compare findings due to methodologic and sample variation, this appears to be a faster decline than had been shown by Hely et al.,4 who reported 48% of patients with PD to have dementia by 15 years, and Buter et al.,5 who showed that 60% had dementia by 12 years.
- © 2015 American Academy of Neurology
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