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July 21, 2015; 85 (3) Clinical/Scientific Notes

Plasma IP-10 level distinguishes inflammatory myopathy

Akinori Uruha, Satoru Noguchi, Wakiro Sato, Hiroaki Nishimura, Satomi Mitsuhashi, Takashi Yamamura, Ichizo Nishino
First published July 1, 2015, DOI: https://doi.org/10.1212/WNL.0000000000001767
Akinori Uruha
From the Translational Medical Center (A.U., S.N., S.M., I.N.) and the National Institute of Neuroscience (A.U., S.N., W.S., H.N., S.M., T.Y., I.N.), National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan.
MD
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Satoru Noguchi
From the Translational Medical Center (A.U., S.N., S.M., I.N.) and the National Institute of Neuroscience (A.U., S.N., W.S., H.N., S.M., T.Y., I.N.), National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan.
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Wakiro Sato
From the Translational Medical Center (A.U., S.N., S.M., I.N.) and the National Institute of Neuroscience (A.U., S.N., W.S., H.N., S.M., T.Y., I.N.), National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan.
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Hiroaki Nishimura
From the Translational Medical Center (A.U., S.N., S.M., I.N.) and the National Institute of Neuroscience (A.U., S.N., W.S., H.N., S.M., T.Y., I.N.), National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan.
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Satomi Mitsuhashi
From the Translational Medical Center (A.U., S.N., S.M., I.N.) and the National Institute of Neuroscience (A.U., S.N., W.S., H.N., S.M., T.Y., I.N.), National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan.
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Takashi Yamamura
From the Translational Medical Center (A.U., S.N., S.M., I.N.) and the National Institute of Neuroscience (A.U., S.N., W.S., H.N., S.M., T.Y., I.N.), National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan.
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Ichizo Nishino
From the Translational Medical Center (A.U., S.N., S.M., I.N.) and the National Institute of Neuroscience (A.U., S.N., W.S., H.N., S.M., T.Y., I.N.), National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan.
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Plasma IP-10 level distinguishes inflammatory myopathy
Akinori Uruha, Satoru Noguchi, Wakiro Sato, Hiroaki Nishimura, Satomi Mitsuhashi, Takashi Yamamura, Ichizo Nishino
Neurology Jul 2015, 85 (3) 293-294; DOI: 10.1212/WNL.0000000000001767

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Discrimination of idiopathic inflammatory myopathy (IIM) from other muscle diseases is at times difficult in clinical practice even after muscle biopsy.1

Acknowledgments

Acknowledgment: The authors thank Hiromi Yamaguchi (Department of Immunology, National Institute of Neuroscience [NIN], NCNP), Kanako Goto (Department of Neuromuscular Research, NIN, NCNP), and Dr. Shigeaki Suzuki (Department of Neurology, Keio University School of Medicine) for support.

Footnotes

  • Supplemental data at Neurology.org

  • Author contributions: A.U. was involved in the conceptualization and design of the study, data analysis and interpretation, literature review, and drafting the manuscript. S.N., W.S., H.N., and S.M. were involved in technical or material support, data interpretation, and manuscript revision for intellectual content. T.Y. was involved in the supervision of data analysis and interpretation and manuscript revision for intellectual content. I.N. was involved in the supervision of all aspects, including study design and data analysis and interpretation, and manuscript revision for intellectual content.

  • Study funding: Supported by JSPS KAKENHI (26860679, 25461323, and 26293214), Intramural Research Grant (26-8 and 23-5) for Neurological and Psychiatric Disorders of NCNP, and the Health and Labour Sciences Research Grants on Research on Development of New Drugs from the Ministry of Health, Labour and Welfare of Japan.

  • Disclosure: A. Uruha reports a grant from JSPS KAKENHI, grant number 26860679. S. Noguchi, W. Sato, H. Nishimura, S. Mitsuhashi, and T. Yamamura report no disclosures relevant to the manuscript. I. Nishino reports grants from Intramural Research Grant (23-5 and 26-8) for Neurological and Psychiatric Disorders of NCNP; JSPS KAKENHI, grant number 26293214; and research grants on rare and intractable diseases from the Ministry of Health, Labour, and Welfare. Go to Neurology.org for full disclosures.

  • Received January 7, 2015.
  • Accepted in final form March 18, 2015.
  • © 2015 American Academy of Neurology
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