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Hereditary motor and sensory neuropathy (HMSN), also known as Charcot-Marie-Tooth disease (CMT), is a genetically heterogeneous disorder that affects both sensory and motor peripheral nerves. HMSN is characterized by distal and symmetric muscle atrophy in the lower limbs and hands, foot abnormalities, and distal sensory loss. It is associated with more than 50 causative genes or loci; however, the genetic cause remains undetermined in almost 50% of HMSN cases.1,2
Acknowledgments
Acknowledgment: The authors thank the family for their participation in this study.
Footnotes
Supplemental data at Neurology.org
Author contributions: Study conception, design, and organization: Shi, Song, and Xu. Acquisition of data: Shi, Luo, Mao, Shang, Cao, and Xu. Analysis and interpretation of data: Shi, Song, Sun, Wu, Zhuang, and Xu. Drafting of the manuscript: Shi, Luo, and Xu. Obtaining funding: Shi and Xu. Administrative, technical, and material support: Shi, Luo, Mao, Shang, and Cao. Study supervision: Shi, Song, Sun, and Xu.
Study funding: This work was supported by grant 81471158 from the National Natural Science Foundation of China (to Dr. Yu-ming Xu) and grant U1404311 from the National Natural Science Foundation of China (to Dr. Chang-he Shi).
Disclosure: The authors report no disclosures relevant to the manuscript. Go to Neurology.org for full disclosures.
- Received January 8, 2015.
- Accepted in final form March 26, 2015.
- © 2015 American Academy of Neurology
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