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Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is an inflammatory disorder of the CNS with distinct clinical and radiologic features.1 In this study, we report an atypical case of CLIPPERS presenting with prominent spinal symptoms and diffuse white matter involvement. Our patient exhibited a good response to steroid therapy and recovered fully, suggesting there are variations in the clinical and radiologic presentations of CLIPPERS, and highlighting the importance of recognizing this rare syndrome as a potentially treatable disorder.
Footnotes
Author contributions: Yin-Xi Zhang: participated in the patient's diagnosis, treatment, and follow-up, conceptualized and designed the study, collected the data, drafted the initial manuscript, and approved the final manuscript as submitted. Hai-Tao Hu: participated in the patient's diagnosis, treatment, and follow-up, conceptualized and designed the study, and approved the final manuscript as submitted. Xiao-Yan Ding: participated in the patient's diagnosis and treatment, collected and analyzed the data, and approved the final manuscript as submitted. Lin-Hui Chen: participated in the patient's diagnosis and treatment, collected the data, and approved the final manuscript as submitted. Ye Du: participated in the patient's diagnosis and treatment, collected and analyzed the data, and approved the final manuscript as submitted. Chun-Hong Shen: participated in the patient's diagnosis and treatment, analyzed the data, and approved the final manuscript as submitted. Yi Guo: participated in the patient's diagnosis and treatment, analyzed the data, and approved the final manuscript as submitted. Mei-Ping Ding: participated in the patient's diagnosis, treatment, and follow-up, conceptualized and designed the study, coordinated and supervised data collection, critically reviewed and revised the manuscript, and approved the final manuscript as submitted.
Study funding: No targeted funding reported.
Disclosure: The authors report no disclosures relevant to the manuscript. Go to Neurology.org for full disclosures.
- Received April 2, 2015.
- Accepted in final form August 27, 2015.
- © 2015 American Academy of Neurology
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Letters: Rapid online correspondence
- Re: Steroid responsive leukoencephalopathy in a CLIPPERS patient
- Steroid responsive leukoencephalopathy in a CLIPPERS patient
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