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July 05, 2016; 87 (1) Clinical/Scientific Notes

Temozolomide induces radiologic pseudoprogression and tumor cell vanishing in oligodendroglioma

Aurelio Hernandez-Lain, Amaya Hilario, Juan Manuel Sepulveda, Diana Cantero, Ana Ramos, Angel Perez-Nuñez
First published June 1, 2016, DOI: https://doi.org/10.1212/WNL.0000000000002810
Aurelio Hernandez-Lain
From Hospital Universitario 12 de Octubre, Madrid, Spain.
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Amaya Hilario
From Hospital Universitario 12 de Octubre, Madrid, Spain.
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Juan Manuel Sepulveda
From Hospital Universitario 12 de Octubre, Madrid, Spain.
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Diana Cantero
From Hospital Universitario 12 de Octubre, Madrid, Spain.
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Ana Ramos
From Hospital Universitario 12 de Octubre, Madrid, Spain.
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Angel Perez-Nuñez
From Hospital Universitario 12 de Octubre, Madrid, Spain.
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Temozolomide induces radiologic pseudoprogression and tumor cell vanishing in oligodendroglioma
Aurelio Hernandez-Lain, Amaya Hilario, Juan Manuel Sepulveda, Diana Cantero, Ana Ramos, Angel Perez-Nuñez
Neurology Jul 2016, 87 (1) 114-115; DOI: 10.1212/WNL.0000000000002810

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This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Diagnosis of radiologic pseudoprogression remains a challenge because its radiologic pattern is often indistinguishable from tumor recurrence.1 Pseudoprogression has been attributed to radiation therapy; the role of chemotherapy in pseudoprogression is uncertain.

Acknowledgments

Acknowledgment: The authors thank Dr. Joaquin Arenas, director of Instituto de Investigación Hospital 12 de Octubre (i+12), for correcting this manuscript.

Footnotes

  • Author contributions: Dr. Hernandez-Lain: project conception, project organization, project execution, imaging, writing first draft, manuscript review and critique. Dr. Hilario: project conception, imaging, manuscript review and critique. Dr. Sepulveda: manuscript review and critique. Diana Cantero: project execution. Dr. Ramos: manuscript review and critique. Dr. Perez-Nuñez: project conception, imaging, manuscript review and critique.

  • Study funding: Supported by grant FIS-PI13/01258 from the Fondo de Investigaciones Sanitarias of the Instituto de Salud Carlos III, Ministerio de Economía y Competitividad.

  • Disclosure: The authors report no disclosures relevant to the manuscript. Go to Neurology.org for full disclosures.

  • Received December 8, 2015.
  • Accepted in final form March 24, 2016.
  • © 2016 American Academy of Neurology
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