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In the current issue of Neurology®, Werden et al.1 examined a group of patients experiencing first-ever or recurrent stroke to understand the relationships between stroke and cortical structural integrity. They performed 3T magnetic resonance scanning within 6 weeks of the most recent stroke and found that stroke patients had smaller hippocampal volumes and greater white matter hyperintensity (WMH) volume compared to controls. Because of the short time lag from stroke to scan, the authors do not believe that the index stroke itself caused the shrinkage in the hippocampus; rather, they believe that the stroke and the structural change in the white matter and hippocampus resulted from a common underlying process.
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