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Checkpoint proteins reduce immune-mediated responses to promote self-tolerance and prevent autoimmunity. Programmed cell death protein 1 (PD-1) is a checkpoint receptor protein expressed on leukocytes that inactivates T cell–mediated immunity when bound to ligand PD-L1. Certain tumors can escape immune-mediated destruction by expressing high concentrations of PD-L1, evading host surveillance.1 PD-1 pathway inhibitors effectively treat multiple malignancies including melanoma, non-small cell lung cancer, and squamous cell carcinoma.2 However, there is increasing recognition of immune-related adverse events (irAE) associated with checkpoint inhibitor therapy due to dysregulated immune system activation.1 We report immune-mediated cerebellitis following pembrolizumab.
Footnotes
Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
- Received November 13, 2017.
- Accepted in final form March 22, 2018.
- © 2018 American Academy of Neurology
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